Comment 43 for bug 41301

I'm having exactly same problem. Once in a while mouse buttons stop working, the pointer moves and keyboard still works. I'm also having dual-screen configuration with Xinerama and two Radeon graphics cards.

I also noted another bug with might be related. I use synergy to share my keyboard and mouse with a laptop which has also Ubuntu 8.10 as does the synergy-server (with those two screens on xinerama). When I move my mouse to the laptop and move it back to the synergy server screen the mouse buttons won't work anymore, exactly like described above. And there is two options to get the buttons to work: a) restart X with ctrl+alt+backspace b) kill the synergy-client on laptop. What's the most curious is that even if the mouse buttons stop working randomly without synergy even running the option b helps (of course you have to start synergy and move mouse to the laptop's screen in that case).