Comment 271 for bug 41301
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| bandito (bandito) wrote look at that nice stuff | #271 |
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0e1f616
(Get the code!)
Yo!
Look at that great and extremely interesting products, it's admired by more and more people, I'm sure you'll enjoy it) Please, take a look http://
Faithfully, Teri Campbell
From: Bug 41301 [mailto:<email address hidden>]
Sent: Wednesday, September 20, 2017 7:22 AM
To: <email address hidden>
Subject: Yeah for real
It is going to be difficult to gauge that now. At one point, scientists speculated that there could be ~100,000 genes in the human genome. The genome project and continued investigation has seen that number drop to an estimated 15k-25k. This may seem like a pretty low number of genes considering the complexity of humans and all of the things our bodies do. However, all of this investigation into genes and how they function has revealed many intricate gene regulatory mechanisms that are not understood. These include epigenetic regulation, splicing and alternative transcripts, tissue specific regulation, and many many more.
During the same time, there has been vast effort to try to discover genes that are "responsible" for disease and differential phenotypes, but these efforts have been largely unsuccessful. What we are finding out is that many of these phenomenons are not directly caused by the malfunction of one or many genes. There are signs that some of these diseases might be caused by differential regulation and expression of genes. Gaining an understanding of these processes is difficult because of limited knowledge combined with the fact that there are only so many experiments that can be ethically conducted on humans. So, scientists turn to model organisms to study these processes. The finding that octopuses (octopi?) have high levels of RNA editing and regulation means that they might be a good place to gain better knowledge of how this is done at a cellular level.
Hopefully, an understanding of these processes translates into human health by allowing us to find causes of disease. Humans may not ever regulate RNA at the same level as octopuses, but it's likely that there are many similarities between RNA regulation in humans and octopuses due to evolution.
Hopefully this helps a little.
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