Comment 1 for bug 198453

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Mary Gardiner (puzzlement) wrote : Re: PulseAudio prevents programs relying on ALSA to work correctly

Partially confirmed: I have had the same problem with Skype and aplay, I have not yet tried the /etc/asound.conf workaround.

A workaround (NOT a fix) is apparently to run applications like this:

pasuspender skype